Skip to main content

Table 6 KRAS and PIK3CA mutations in cervical cancer

From: Epidermal growth factor receptor pathway mutation and expression profiles in cervical squamous cell carcinoma: therapeutic implications

References

Squamous cell carcinoma

Adenocarcinoma/other

KRAS mutation

PIK3CA mutation

KRAS mutation

PIK3CA mutation

Dokianakis et al. [50]a

0/10 (0%)1

2/2 (100%)1

Stenzel et al. [51]b

3/22 (13.6%)2

1/2 (50.0%)2

Pappa et al. [52]a

2/28 (7.1%)3

1/19 (5.3%)3

Miyake et al. [53]c

2/12 (16.7%)i

1/9 (11.1%)i

Cui et al. [38]d

5/84 (6.0%)ii

10/100 (10.0%)ii

Iida et al. [18]c

0/32 (0%)4

3/48 (6.3%)4

Janku et al. [54]e

i2/8 (25.0%)

0/7 (0%)i

Janku et al. [55]e

1/10 (10%)4

5/14 (35.7%)i

Janku et al. [40]e

6/18 (33.3%)i

Wright et al. [19]e

0/40 (0%)5

15/40 (37.5%)iii

7/40 (17.5%)5

10/40 (25.0%)iii

McIntyre et al. [39]f

16/69 (23.2%)i

3/13 (23.1%)i

Ojesina et al. [48]g

1/79 (1.3%)6

9/79 (11.4%)iv

2/35 (5.7%)6

8/35 (22.9%)iv

Rashmi et al. [32]e

6/120 (5.0%)iii

2/20 (10.0%)iii

Spaans et al. [47]h

9/205ns (4.4%)5

50/205ns (24.4%)iii

Ns

Ns

Tornesello et al. [56]i

3/55 (5.5%)v

The present studyj

0/91 (0%)7

19/95 (20.0%)vi

  1. Specimen country of origin: a Greece, b Poland, c Japan, d Sweden, e USA, f Canada, g Norway and Mexico, h The Netherlands, i Italy, and j India. KRAS mutation methodology: 1 codon 12 PCR/sequencing, 2 codon 12 PCR–RFLP/SSCP, 3 codons 12, 13 and 16 PCR/sequencing, 4 codons 12 and 13 PCR/sequencing, 5 sequenom MALDI-TOFF massARRAY, 6 exome/whole genome Illumina HiSeq 200, 7 codons 12 and 13 PNA-Clamp PCR. PIK3CA mutation methodology: i exons 9 and 20 PCR/sequencing, ii exons 1, 9 and 20 PCR/sequencing, iii sequenom MALDI-TOF massARRAY, iv exome/whole genome Illumina HiSeq 200, v exon 9 nested PCR/sequencing, vi exons 9 and 20 PNA-Clamp PCR. ns not specified whether specimens were squamous cell carcinoma or adenocarcinoma.