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Table 5 Summary of staining patterns that included statistically significant associations

From: Epidermal growth factor receptor pathway mutation and expression profiles in cervical squamous cell carcinoma: therapeutic implications

Marker

PIK3CA wild type (n = 19)

PIK3CA mutant (n = 72)

 

P value

EGFR mean AS

2.4 (2.6)

3.8 (2.7)

 

0.043*

EGFR HL AS

12

23

 

0.018 ** (OR = 3.652)

EGFR LL AS

49

7

 

Lymph node negative (n = 65)

Lymph node positive (n = 21)

  

EGFR mean AS

2.9 (2.5)

1.7 (2.5)

 

0.047

EGFR HL AS

26

4

 

0.114*

EGFR LL AS

39

17

 

Well differentiated (n = 8)

Moderately differentiated (n = 67)

Poorly differentiated (n = 26)

 

EGFR mean AS

4.3 (2.5)

2.2 (2.5)

3.4 (2.8)

0.029 ***

EGFR HL AS

5

21

12

0.351a,*

EGFR LL AS

3

46

14

 

Lymph node negative (n = 65)

Lymph node positive (n = 21)

  

p-AKT cytoplasmic mean AS

4.9 (2.3)

5.8 (2.2)

 

0.027 *

p-AKT cytoplasmic

 HL AS

52

18

 

0.751**

 LL AS

13

3

 
 

Well differentiated (n = 8)

Moderately differentiated (n = 65/66)

Poorly differentiated (n = 27)

 

p-AKT cytoplasmic mean AS

6.6 (0.5)

5.4 (2.0)

4.5 (2.3)

0.009 ***

p-AKT cytoplasmic

   

0.518a,*

 HL AS

8

56

22

 

 LL AS

0

9

5

p-AKT nuclear mean AS

5.1 (3.1)

3.3 (3.0)

2.0 (2.7)

0.014 ***

p-AKT nuclear

   

0.178a,*

 HL AS

5

35

10

 

 LL AS

3

31

17

  1. AS (Allred Score), High Level (HL) AS (AS ≥4), Low Level (LL) AS (AS <4).
  2. Italic values indicate statistically significant.
  3. * Mann–Whitney test.
  4. ** Fisher’s Exact test.
  5. ** Kruskall-Wallis test.
  6. aWell and moderate categories combined.
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Journal of Translational Medicine

ISSN: 1479-5876

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