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Table 4 Summary of marker panel staining patterns

From: Epidermal growth factor receptor pathway mutation and expression profiles in cervical squamous cell carcinoma: therapeutic implications

Marker

Negative

Low

Intermediate

High

EGFR (n = 101)

41 (40.6%)

22 (21.8%)

26 (25.7%)

12 (11.9%)

PIK3CA (n = 101)

1 (1.0%)

0 (0%)

13 (12.9%)

87 (86.1%)

PTEN (n = 100)

69 (69.0%)

5 (5.0%)

26 (26.0%)

0 (0%)

p-mTOR (n = 101)

37 (36.6%)

22 (21.8%)

41 (40.6%)

1 (1.0%)

p-AKT cytoplasmic (n = 101)

11 (10.9%)

5 (5.0%)

47 (46.5%)

38 (37.6%)

p-AKT nuclear (n = 101)

45 (44.6%)

4 (4.0)

31 (30.7%)

21 (20.8%)

p-MAPK/Erk1/2 cytoplasmic (n = 102)

31 (30.4%)

14 (13.7%)

57 (55.9%)

0 (0%)

p-MAPK/Erk1/2 nuclear (n = 102)

27 (26.5%)

11 (10.8%)

64 (62.7%)

0 (0%)

  1. Each antibody was reviewed with respect to the proportion of cells staining: 0 = Negative; 1 = Rare cell positive (< 1%); 2 = Focally positive (1–25%); 3 = Variably positive (25–75%); 4 = Uniformly positive (>75%); and in terms of staining intensity: 0 = Negative; 1 = weakly positive; 2 = moderately positive; and 3 = strong positive. These scores were summed to give an Allred score (AS) ranging from 0 to 7. Staining data is summarized in the above table as: Negative, (AS = 0–1), Low (AS = 2–3), Intermediate (AS = 4–6), High (AS = 7).