Integrated analysis of miRNA, gene, and pathway regulatory networks in hepatic cancer stem cells

Table 2 Details of target genes regulated by differentially expressed miRNAs

miRNA	Up/down-regulation of miRNA (HCSC/HCC)	Number of target genes
miRNA	Up/down-regulation of miRNA (HCSC/HCC)	Total predicted targets	Differentially expressed targets	Up-regulated targets (HCSC/HCC)	Down-regulated targets (HCSC/HCC)	Candidate targets
hsa-miR-100	Down	574	22	4	18	4
hsa-miR-210	Down	1180	33	5	28	5
hsa-miR-29c	Down	3533	99	26	73	26
hsa-miR-181c	Down	5492	141	15	126	15
hsa-miR-22*	Down	2343	55	4	51	4
hsa-miR-15b*	Down	1641	45	4	41	4
hsa-miR-199a-3p	Down	3707	99	11	88	11
hsa-miR-199b-3p	Down	3456	96	10	86	10
hsa-miR-149	Down	5100	116	24	92	24
hsa-miR-378d	Up	7	0	0	0	0
hsa-miR-450b-5p	Up	5865	146	8	138	138
hsa-miR-338-5p	Up	5240	156	15	141	141
hsa-miR-760	Up	4249	113	32	81	81
hsa-miR-378	Up	3486	92	20	72	72
hsa-miR-215	Up	2878	81	11	70	70
hsa-miR-375	Up	3312	95	10	85	85
hsa-miR-1269b	Up	12	0	0	0	0
hsa-miR-1269	Up	2877	71	7	64	64

Seven miRNA target computational prediction sources were used to identify the interactions of miRNAs and genes. The miRNA-target interactions which occurred in at least two of these sources were considered. For each miRNA, the expression level of the target genes in HCSC and HCC was considered. The detail result is listed in this table

ISSN: 1479-5876