Fig. 2
From: Prognostic relevance of LGALS3BP in human colorectal carcinoma
LGALS3BP knock-down affects growth of tumor xenografts and is associated with a reduction in β-catenin expression. a HCT-116shctrl and HCT-116shLGALS3BP cells were implanted s.c. into the right flank of female nude mice (9 mice for HCT-116shctrl; 15 mice for HCT-116shLGALS3BP). Tumor growth was assessed as described in “Methods”. *p < 0.05. b Examples of immunohistochemical staining of β-catenin in HCT-116shctrl and HCT-116shLGALS3BP xenografts (scale bar 20 μm). c Animals harboring HCT-116shLGALS3BP xenografts (approximately 200 mm3) were randomly divided into two groups (indicated by the arrow); tumors from one group were injected intra-lesionally with 100 μg LGALS3BP in 50 μL PBS, the other injected with the same volume of PBS. Injections were made twice a week. Tumor growth was assessed as described in “Methods”. (*p < 0.05).