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Table 1 Main characteristics of the different groups

From: Increased ex vivo cell death of central memory CD4 T cells in treated HIV infected individuals with unsatisfactory immune recovery

  Discordant (n = 23) a Concordant b Uninfected (n = 11)
All (n = 33) Low Nadir (n = 17) High Nadir (n = 16)
Age (years), Median [IQR] 48 [45–50] ns 45 [38–49] 48 [42–52] 42 [37–45] ns 38 [34–47]
Gender (% of male) 91 ns 85 76 94 ns 55
Time since HIV diagnosis (years), Median [IQR] 10.1 [4.1–20.4] ns 11.8 [7.5–16.6] 12.2 [8.9–17.4] 11.6 [4.9–13.4] ns
Time on HAART (years), Median [IQR] 5.2 [3.5–11.4] ns 11.2 [7.4–12.6] 11.4 [8.8–12.6] 10.6 [3.7–12.8] ns
Current HAART (% PI-based) 70 * 33 41 25 *
HCV coinfection (%) 35 ns 21 36 15 * 0
Ratio CD4/CD8, Median [IQR] 0.23 [0.17–0.33] * 0.87 [0.60–1.11] 0.76 [0.54–0.87] 1.06 [0.86–1.1] ns 1.64 [1.31–1.81]
CD4 T cell counts (cells/µL), Median [IQR] 220 [192–253] * 798 [600–998] 703 [600–896] 881 [672–1,075] ns 779 [629–1,072]
Nadir (cells/µL), Median [IQR] 64 [15–122] * 239 [76–345] 76 [19–185] 351 [280–429] *
CD4 T-cell gain (cell/µL/year HAART), Median [IQR] 27 [9–54] * 53 [46–102] 53 [46–93] 53 [36–124] ns
CD4 T cell (% of lymph), Median [IQR] 14 [10–17] * 31 [27–39] 29 [27–33] 37 [29–40] ns 42 [36–45]
CD4 T-cell death (%), Median [IQR] 9.3 [7.5–15.1] * 4.6 [3.3–5.9] 4.9 [4.4–5.6] 4.3 [2.9–6.1] ns 4.0 [3.2–4.7]
CD38+CD45RA (% of CD4 T cells), Median [IQR] 37 [29–41] * 25.7 [20–32] 26.5 [20–32] 25.1 [20–31] ns  
HLA-DR+CD95+ (% of CD4 T cells), Median [IQR] 16 [7.7–21.6] * 4.5 [3.7–6.7] 4.7 [4.2–6.3] 4.4 [3.2–7.1] ns 2.0 [1.5–2.7]
CD8 T cell counts (cells/µL), Median [IQR] 940 [754–1,146] ns 908 [771–1,239] 1,118 [855–1,380] 811 [637–1,121] ns 459 [433–548]
CD8 T cell (% of lymph), Median [IQR] 56 [51–61] * 38 [34–46] 39 [36–47] 36 [32–40] ns 24 [23–27]
CD8 T cell death (%), Median [IQR] 7.1 [4.8–10.3] ns 6.5 [5.0–12.4] 8.8 [6.1–11.0] 6.1 [4.8–14.9] ns 3.9 [3.4–4.9]
CD38+CD45RA (% of CD8 T cells), Median [IQR] 31 [23–36] * 23 [19–35] 25 [21–36] 21 [19–26] ns 9 [5–13]
HLA-DR+CD95+ (% of CD8 T cells), Median [IQR] 12.6 [6.9–22.4] ns 9.1 [5.6–13.0] 9.8 [5.4–13.6] 8.5 [5.6–13.0] ns  
sCD14 (µg/mL), Median [IQR] 8.4 [7.7–10.2] ns 8.8 [7.2–9.7] 9.2 [7.6–10.1] 8.0 [7.1–9.2] ns 4.2 [3.9–4.6]
  1. a Comparison of concordant and discordant subjects. * denotes p < 0.05; ns non significant (Mann–Withney U or Fisher exact test).
  2. b Comparison of concordant subjects with low and high nadir. * denotes p < 0.05; ns non significant (Mann–Withney U or Fisher exact test).