Characterization of CD8 T-cell subsets. The absolute number of circulating and TN, TCM, TTM, TEM and TTD CD8 T cells (a) was analyzed in immunodiscordant individuals (n = 23, red boxes), immunoconcordant individuals with low or high nadir (n = 17 and n = 16, dark and light green boxes, respectively) and healthy HIV uninfected individuals (n = 11, blue boxes). The frequency of the above-mentioned subsets in the CD8 T cell compartment (b) was also analyzed. The expression of CD57+ cells was further evaluated in the different subsets by the frequency of CD57+ cells (c). In all panels data shown correspond to median values (bands), IQR (boxes) and 10–90 interquartile values (whiskers) for immunodiscordant individuals (red boxes), immunoconcordant individuals with low or high nadir (green boxes) and healthy HIV uninfected individuals (blue boxes). Figure show p
values (permutation test adjusted by false discovery rate).