Characterization of CD4 T-cell subsets. a shows the evolution of CD4 T-cell counts in the three groups defined in this study (Immunodiscordant in red (n = 23), immunoconcordant with low and high nadir in dark and light green, m = 17 and n = 16, respectively). Dots correspond to individual determinations of CD4 T-cell counts and lines show non-lineal regression of data plotted for comparative purposes. b The absolute count of circulating and TN, TCM, TTM, TEM and TTD CD4 T cells was analyzed in immunodiscordant individuals (red boxes), immunoconcordant individuals with low or high nadir (LN and HN; dark and light green boxes, respectively) and healthy HIV uninfected individuals (n = 11, blue boxes). c The frequencies of the above-mentioned subsets in the CD4 T-cell compartment were also analyzed. In panels
b and c, data shown correspond to median values (band), IQR (boxes) and 10–90 interquartile values (whiskers). Figure show significant p
values (permutation test adjusted by false discovery rate): *p < 0.05; **p < 0.01 and ***p < 0.005.