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Table 5 Effect on antioxidant enzymes and GSH levels in liver, kidney, heart, brain and testes in absence (CdCl2) and presence of AEIA (AEIA + CdCl2) and AEEF (AEEF + CdCl2) in mice

From: The effects of two common edible herbs, Ipomoea aquatica and Enhydra fluctuans, on cadmium-induced pathophysiology: a focus on oxidative defence and anti-apoptotic mechanism

Parameters Group Liver Kidney Heart Brain Testes
CAT (U/mg of protein) I 312.92 ± 27.65 248.22 ± 21.24 313.24 ± 21.33 94.12 ± 6.67 41.25 ± 3.87
II 178.43 ± 16.86# 128.30 ± 14.04# 192.56 ± 17.04# 46.45 ± 3.92# 25.54 ± 3.01$
III 279.88 ± 25.46** 221.33 ± 23.78** 267.54 ± 16.92* 69.75 ± 6.78* 38.76 ± 2.98*
IV 264.20 ± 27.11* 214.34 ± 17.67* 261.41 ± 18.00* 67.22 ± 5.98 35.43 ± 3.93
SOD (U/mg of protein) I 82.17 ± 7.21 78.02 ± 6.89 134.69 ± 10.17 94.52 ± 6.25 119.42 ± 8.13
II 45.83 ± 4.34# 42.34 ± 4.71# 78.35 ± 8.92# 52.24 ± 5.08# 78.34 ± 7.78$
III 76.51 ± 6.94** 72.86 ± 6.94** 119.85 ± 11.01* 78.92 ± 7.38* 111.85 ± 9.25*
IV 75.33 ± 6.23** 69.87 ± 7.18* 119.61 ± 9.87* 73.05 ± 7.01 103.61 ± 9.96
GST (µmol/h/mg protein) I 1.28 ± 0.18 1.34 ± 0.11 0.64 ± 0.06 1.75 ± 0.15 4.51 ± 0.36
II 0.59 ± 0.07# 0.68 ± 0.05# 0.42 ± 0.03# 1.24 ± 0.09$ 2.45 ± 0.21#
III 1.16 ± 0.14* 1.21 ± 0.10** 0.61 ± 0.04* 1.67 ± 0.09* 3.91 ± 0.40*
IV 1.14 ± 0.09* 1.20 ± 0.08* 0.59 ± 0.05* 1.65 ± 0.12 3.78 ± 0.33*
GPx (nmol/min/mg protein) I 123.85 ± 6.67 43.62 ± 3.78 312.15 ± 16.33 165.43 ± 8.94 162.05 ± 7.65
II 78.50 ± 4.42# 26.95 ± 2.21# 206.96 ± 12.28# 121.35 ± 6.67# 112.33 ± 6.10#
III 108.50 ± 5.33** 39.28 ± 2.89* 278.36 ± 17.82* 155.85 ± 8.12* 148.76 ± 6.05**
IV 102.05 ± 5.12* 38.47 ± 3.01* 272.84 ± 14.95* 148.33 ± 7.33 142.50 ± 7.02*
GR (nmol/min/mg protein) I 88.85 ± 6.33 34.51 ± 2.87 82.17 ± 4.01 48.12 ± 4.49 85.10 ± 4.54
II 61.78 ± 4.18# 19.33 ± 2.02# 42.76 ± 2.19# 28.94 ± 2.86# 52.95 ± 4.20#
III 84.33 ± 8.02* 31.24 ± 2.49** 63.21 ± 3.77** 40.70 ± 3.55 69.43 ± 3.36*
IV 77.36 ± 5.79 29.72 ± 1.92* 58.76 ± 3.54* 38.29 ± 3.02 63.21 ± 4.47
G6PD (nmol/min/mg protein) I 104.32 ± 9.12 86.74 ± 7.12 98.32 ± 5.14 34.68 ± 3.06 54.25 ± 4.72
II 54.31 ± 5.76# 45.17 ± 3.22# 69.28 ± 4.21# 19.43 ± 2.33# 34.56 ± 2.89#
III 86.08 ± 7.11* 72.16 ± 5.15** 89.67 ± 4.75* 26.54 ± 1.76 46.29 ± 3.16
IV 85.33 ± 6.58* 67.21 ± 4.99* 86.23 ± 4.77 25.33 ± 1.58 45.02 ± 3.04
GSH (nmol/mg protein) I 24.21 ± 2.54 16.54 ± 1.01 19.51 ± 2.01 27.12 ± 2.67 17.65 ± 1.87
II 13.21 ± 1.69# 8.33 ± 0.82# 9.34 ± 1.54# 13.25 ± 1.48# 9.67 ± 1.00#
III 21.88 ± 2.05* 13.45 ± 1.15** 15.43 ± 1.67* 18.24 ± 1.92* 15.67 ± 1.24*
IV 21.35 ± 1.90* 12.67 ± 0.98* 14.45 ± 1.48 19.12 ± 1.78 15.02 ± 1.61*
  1. Values are expressed as mean ± SE, for six animals in each group. #Values differ significantly from normal control (p < 0.01). $ Values differ significantly from normal control (p < 0.05). * Values differ significantly from CdCl2 control (p < 0.05). ** Values differ significantly from CdCl2 control (p < 0.01). Group I: Normal control; Group II: Toxic control; Group III: AEIA (100 mg/kg) + CdCl2 (4 mg/kg); Group IV: AEEF (100 mg/kg) + CdCl2 (4 mg/kg).