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Table 1 Meningioma cell lines reported in the literature

From: Development of patient-derived xenograft models from a spontaneously immortal low-grade meningioma cell line, KCI-MENG1

Cell line

References

Source

Manipulation

IHC

Morphology

Telomerase

Cytogenetics

Genomics

Xenograft tumor

KT21-MG1

Tanaka et al. [8]

Grade III

None

Vimtentin+

GFAP−

Round and spindle

n/a

Shows loss of chromosome 22

Southern blotting

Grew

IOMM-Lee

Lee [6]

Grade III

None

Vimentin+

S-100−

Estrogen receptor−

GFAP−

FVIII-RA−

EMA−

NSE−

Leukocyte common antigen−

Keratin−

Actin−

Neurofilaments−

Mostly round, some spindles though

n/a

45–65 chromosomes, model number of 49, no loss of chromosome 22

n/a

Grew, but no indication as to the method of injection

MENII-1

Striedinger et al. [13]

Grade II

Telomerase expression and HPV E6/E7

Merlin+

YAP

Round

n/a

n/a

n/a

n/a

CH-157MN

Tsai et al. [34]

Unknown grade

n/a

VEGF+

Spindles

n/a

n/a

n/a

n/a

HKBMM

Ishiwata et al. [9]

Grade III

n/a

Desmin+

PKK-1+

S-100−

EMA−

Vimentin+

Spindles

n/a

Model number of 48, 21p+, aneuploidy

n/a

Subcutaneous

BEN-MEN-1

Puttmann et al. [11]

Grade I

hTERT

GFAP−

Vimentin+

EMA+

PR−

Estrogen Rec−

Cytokeratins−

Ki-67−

Mostly spindles, few scattered round cells

RT-PCR, TRAP assay and Southern blotting

Loss of one chromosome 22 in all cells, while other chromosomal changes were absent (45, XX, 22)

n/a

Subdural (subarachnoidal)

F5

Yazaki et al. [7]

Grade III

n/a

S-100+

Vimentin+

n/a

n/a

Loss of chromosome 22

n/a

Subcutaneous and intracranial

Me10T

Cargioli et al. [10]

Grade I

hTERT

EMA−

PR−

Vimetin+

S-100+

Cytokeratin+

Round and spindle

Discussed, no data—transduced cells showed activity whereas the non-transduced cells did not

Monosomy only of chromosome 22

n/a

Intracranial—subdural

Me3TSC

Cargioli et al. [10]

Grade I

hTERT and SV40 large T antigen

EMA−

PR−

Vimetin+

S-100+

Cytokeratin+

Round and spindle

Discussed, no data—transduced cells showed activity whereas the non-transduced cells did not

Monosomy for chromosome 22, deletions in chromosomes 9 and 11, and translocations between 1 and 5

n/a

Intracranial—subdural

SF3061-Parental

Baia et al. [12]

Grade III

hTERT

Vimentin+

Desmoplakin+

Spindle

Quantitative PCR

Subset of the losses in the primary tumor: 9p24-p21; 11q23-qtel; 13q12-

q21; 17p

aCGH

n/a

SF4433-Parental

Baia et al. [12]

Grade I

E6/E7-hTERT

Vimentin+

Desmoplakin+

Round and spindle

Quantitative PCR

No chromosomal abnormalities found

aCGH

n/a

SF4068- Parental

Baia et al. [12]

Grade I

E6/E7-hTERT

Vimentin+

Desmoplakin 1 and 2+

NF2−

Spindle

Quantitative PCR

Gain of chromosome 5p and loss of chromosome 15

aCGH

n/a

KCI-MENG1

Michelhaugh (2015-this study)

Grade I

None

EMA+

Vimentin+

N. Cadherin+

PR−

Ki-67+

E. Cadherin−

Low passage: heterogeneous for round and spindle cells

High passage: homogeneous for round cells

TRAP assay

Near triploid, multiple translocations

aCGH

Subcutaneous

Intracranial—subdural