Cell line | References | Source | Manipulation | IHC | Morphology | Telomerase | Cytogenetics | Genomics | Xenograft tumor |
---|---|---|---|---|---|---|---|---|---|
KT21-MG1 | Tanaka et al. [8] | Grade III | None | Vimtentin+ GFAP− | Round and spindle | n/a | Shows loss of chromosome 22 | Southern blotting | Grew |
IOMM-Lee | Lee [6] | Grade III | None | Vimentin+ S-100− Estrogen receptor− GFAP− FVIII-RA− EMA− NSE− Leukocyte common antigen− Keratin− Actin− Neurofilaments− | Mostly round, some spindles though | n/a | 45–65 chromosomes, model number of 49, no loss of chromosome 22 | n/a | Grew, but no indication as to the method of injection |
MENII-1 | Striedinger et al. [13] | Grade II | Telomerase expression and HPV E6/E7 | Merlin+ YAP | Round | n/a | n/a | n/a | n/a |
CH-157MN | Tsai et al. [34] | Unknown grade | n/a | VEGF+ | Spindles | n/a | n/a | n/a | n/a |
HKBMM | Ishiwata et al. [9] | Grade III | n/a | Desmin+ PKK-1+ S-100− EMA− Vimentin+ | Spindles | n/a | Model number of 48, 21p+, aneuploidy | n/a | Subcutaneous |
BEN-MEN-1 | Puttmann et al. [11] | Grade I | hTERT | GFAP− Vimentin+ EMA+ PR− Estrogen Rec− Cytokeratins− Ki-67− | Mostly spindles, few scattered round cells | RT-PCR, TRAP assay and Southern blotting | Loss of one chromosome 22 in all cells, while other chromosomal changes were absent (45, XX, 22) | n/a | Subdural (subarachnoidal) |
F5 | Yazaki et al. [7] | Grade III | n/a | S-100+ Vimentin+ | n/a | n/a | Loss of chromosome 22 | n/a | Subcutaneous and intracranial |
Me10T | Cargioli et al. [10] | Grade I | hTERT | EMA− PR− Vimetin+ S-100+ Cytokeratin+ | Round and spindle | Discussed, no data—transduced cells showed activity whereas the non-transduced cells did not | Monosomy only of chromosome 22 | n/a | Intracranial—subdural |
Me3TSC | Cargioli et al. [10] | Grade I | hTERT and SV40 large T antigen | EMA− PR− Vimetin+ S-100+ Cytokeratin+ | Round and spindle | Discussed, no data—transduced cells showed activity whereas the non-transduced cells did not | Monosomy for chromosome 22, deletions in chromosomes 9 and 11, and translocations between 1 and 5 | n/a | Intracranial—subdural |
SF3061-Parental | Baia et al. [12] | Grade III | hTERT | Vimentin+ Desmoplakin+ | Spindle | Quantitative PCR | Subset of the losses in the primary tumor: 9p24-p21; 11q23-qtel; 13q12- q21; 17p | aCGH | n/a |
SF4433-Parental | Baia et al. [12] | Grade I | E6/E7-hTERT | Vimentin+ Desmoplakin+ | Round and spindle | Quantitative PCR | No chromosomal abnormalities found | aCGH | n/a |
SF4068- Parental | Baia et al. [12] | Grade I | E6/E7-hTERT | Vimentin+ Desmoplakin 1 and 2+ NF2− | Spindle | Quantitative PCR | Gain of chromosome 5p and loss of chromosome 15 | aCGH | n/a |
KCI-MENG1 | Michelhaugh (2015-this study) | Grade I | None | EMA+ Vimentin+ N. Cadherin+ PR− Ki-67+ E. Cadherin− | Low passage: heterogeneous for round and spindle cells High passage: homogeneous for round cells | TRAP assay | Near triploid, multiple translocations | aCGH | Subcutaneous Intracranial—subdural |