| |
HV
|
AML
|
|---|
|
No. patients
|
30
|
30
|
|
Gender
| | |
|
Male
|
15 (50%)
|
14 (47%)
|
|
Female
|
15 (50%)
|
16 (53%)
|
|
Median age, years (range)
|
63 (38–87)
|
68 (35–85)
|
|
Subtype according to FAB classification
|
|
M0–M1
| |
6 (20%)
|
|
M2
| |
9 (30%)
|
|
M4
| |
4 (13.3%)
|
|
M5
| |
9 (30%)
|
|
M6
| |
1 (3.3%)
|
|
M7
| |
1 (3.3%)
|
|
Karyotype
|
|
Normal
| |
14 (47%)
|
|
Undefined
| |
4 (13%)
|
|
Complex
| |
3 (10%)
|
|
Trisomy chr 8
| |
3 (10%)
|
|
t(8–21)
| |
2 (7%)
|
|
Tetrasomy chr 21
| |
1 (3%)
|
|
Inv chr 3
| |
1 (3%)
|
|
Del chr 7
| |
1 (3%)
|
|
Del chr 20
| |
1 (3%)
|
|
Molecular mutations
|
|
FLT3/NPM wt
| |
17 (57%)
|
|
FLT3 ITD
| |
4 (13%)
|
|
FLT3 mut NPM mut
| |
3 (10%)
|
|
FLT3 mut NPM wt
| |
1 (3%)
|
|
FLT3 wt NPM mut
| |
1 (3%)
|
|
AML-ETO
| |
2 (7%)
|
|
Undefined
| |
2 (7%)
|
-
FAB French-American-British, chr chromosome, t translocation, Inv inversion, Del deletion, wt wild type, mut mutated.
