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Table 1 Clinicopathological characteristics of the patients according to the breast cancer stromal histologic phenotype

From: Expression of cancer-associated fibroblast related proteins in metastatic breast cancer: an immunohistochemical analysis

Parameter

Total N = 132 (%)

Desmoplastic type n = 38 (%)

Inflammatory type n = 9 (%)

Pauci-stroma type n = 45 (%)

Sclerotic type n = 40 (%)

p value

Age (years)

     

0.600

 ≤50

68 (51.5)

21 (55.3)

5 (55.6)

25 (55.6)

17 (42.5)

 

 >50

64 (48.5)

17 (44.7)

4 (44.4)

20 (44.4)

23 (57.5)

 

ER

     

0.339

 Negative

63 (47.7)

20 (52.6)

6 (66.7)

22 (48.9)

15 (37.5)

 

 Positive

69 (52.3)

18 (47.4)

3 (33.3)

23 (51.1)

25 (62.5)

 

PR

     

0.060

 Negative

91 (68.9)

28 (73.7)

7 (77.8)

35 (77.8)

21 (52.5)

 

 Positive

41 (31.1)

10 (26.3)

2 (22.2)

10 (22.2)

19 (47.5)

 

HER-2

     

0.370

 Negative

89 (67.4)

28 (73.7)

4 (44.4)

29 (64.4)

28 (70.0)

 

 Positive

43 (32.6)

10 (26.3)

5 (55.6)

16 (35.6)

12 (30.0)

 

Molecular subtypes

     

0.063

 Luminal A

47 (35.6)

15 (39.5)

3 (33.3)

12 (26.7)

17 (42.5)

 

 Luminal B

23 (17.4)

3 (7.9)

0 (0.0)

11 (24.4)

9 (22.5)

 

 HER-2

27 (20.5)

7 (18.4)

5 (55.6)

8 (17.8)

7 (17.5)

 

 TNBC

35 (26.5)

13 (34.2)

1 (11.1)

14 (31.1)

7 (17.5)

 

Ki-67 LI (%)

     

0.139

 ≤14

91 (68.9)

31 (81.6)

6 (66.7)

26 (57.8)

28 (70.0)

 

 >14

41 (31.1)

7 (18.4)

3 (33.3)

19 (42.2)

12 (30.0)

 

Metastasis site

     

< 0.001

 Bone

32 (24.2)

18 (47.4)

0 (0.0)

4 (8.9)

10 (25.0)

 

 Brain

38 (28.8)

3 (7.9)

2 (22.2)

25 (55.6)

8 (20.0)

 

 Liver

10 (7.6)

0 (0.0)

0 (0.0)

0 (0.0)

10 (25.0)

 

 Lung

52 (39.4)

17 (44.7)

7 (77.8)

16 (35.6)

12 (30.0)

 

Patients death

44 (33.3)

15 (39.5)

3 (33.3)

14 (31.1)

12 (30.0)

0.815

  1. Italic value indicates statistically significant (p < 0.05).
  2. TNBC triple negative breast cancer.