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Figure 6 | Journal of Translational Medicine

Figure 6

From: Mesenchymal stromal cells for cutaneous wound healing in a rabbit model: pre-clinical study applicable in the pediatric surgical setting

Figure 6

Histological evaluation of proliferative cellular nuclear antigen (PCNA)-positive nuclei at 11 and 21 days after different MSC treatments. Panels 1, 2 autologous ASC-treated wounds show a high number of PCNA-positive nuclei in epidermal layers. Panels 3, 4 allogeneic ASC wounds display several PCNA-positive cells. Panels 5, 6 in wounds treated with BM-MSCs the number of PCNA-positive cells is low. Panels 7, 8 saline-treated wounds show no epithelial cells marked with PCNA, but a considerable immunopositivity for fibroblasts and endothelial cells was detected. Eschar (asterisk). Immunostaining of PCNA. Scale bar 200 μm; original mag. ×100.

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