Figure 1

Experimental design. Rabbit ASCs and BM-MSCs were collected, isolated and expanded. As soon as an adequate number of in vitro expanded MSCs was reached, two wound lesions (wound 1 and wound 2) were created. Within 5 min from the wound lesion establishment, autologous or allogeneic ASCs or autologous BM-MSCs were directly injected into the wound bed 1. Into wound bed 2, 3 ml of saline 2% rabbit albumin solution was injected as a control. Wound healing was monitored daily. After rabbit euthanasia, biopsies of the regenerated tissues were collected, using dermal biopsy punches, for histological examination.