Figure 4

Effect of febuxostat on mitochondrial structure in mice. a Representative electron micrographs (×50,000) of mitochondrial structures. Sham the structure of mitochondria was generally very good. I/R I/R-induced mitochondrial structural disruption (swelling, rupture and loss of cristae). I/R + FEB febuxostat treatment ameliorated I/R-induced mitochondrial impairment. FEB the structure of mitochondria was basically intact. b Mean area of mitochondria. All values represent mean ± SD. *P < 0.01 vs. Sham, ^# P < 0.01 vs. I/R, n = 4/group, these experiments were performed with similar results.