Effects of febuxostat on apoptosis in mice. a Representative photomicrographs (×200) of TUNEL staining in myocardial I/R tissue. Green fluorescence indicates TUNEL-positive apoptotic nuclei; blue fluorescence indicates total cardiomyocyte nuclei. b Apoptotic index. c Myocardial caspase-3 activity. d Myocardial caspase-9 activity. The results were expressed as mean ± SD (n = 7). The results were expressed as mean ± SD (n = 7). *P < 0.01 vs. Sham, #
P < 0.01, vs. I/R, ¶
P < 0.01 vs. I/R + ALL.