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Table 3 Association of IL7RA haplotypes (rs987106, rs6897932 and rs13126816) with severe liver disease in HIV/HCV coinfected patients

From: Association between IL7R polymorphisms and severe liver disease in HIV/HCV coinfected patients: a cross-sectional study

IL7RA haplotypes Adjusted
rs6897932 rs987106 rs3194051 Freq. Outcomes aOR (95% CI) p value
C T A 47.9% F ≥ 3 2.01 (1.19;3.40) 0.007
     APRI ≥1.5 1.98 (1.06;3.71) 0.028
     FIB4 ≥3.25 2.69 (1.10;6.60) 0.023
     A3 NA
C A G 31.5% F ≥ 3 0.42 (0.22;0.78) 0.004
     APRI ≥1.5 0.45 (0.22;0.94) 0.026
     FIB4 ≥3.25 0.24 (0.07;0.76) 0.007
     A3 NA
T A A 20.1% F ≥ 3 0.86 (0.44;1.67) 0.647
     APRI ≥1.5 0.92 (0.42;2.04) 0.838
     FIB4 ≥3.25 1.07 (0.35;3.26) 0.904
     A3 NA
  1. P values were calculated by multivariate logistic regression adjusted by the most important clinical and epidemiological characteristics (see “Statistical analysis” section). Statistically significant differences are shown in italics.
  2. 95% CI 95% of confidence interval, aOR adjusted odds ratio, p value level of significance, A3 severe activity grade (Metavir), F  3 advanced liver fibrosis (Metavir), APRI aspartate aminotransferase to platelet ratio index, NA not available due to a low number of patients in one of the groups.