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Table 3 Association of IL7RA haplotypes (rs987106, rs6897932 and rs13126816) with severe liver disease in HIV/HCV coinfected patients

From: Association between IL7R polymorphisms and severe liver disease in HIV/HCV coinfected patients: a cross-sectional study

IL7RA haplotypes

Adjusted

rs6897932

rs987106

rs3194051

Freq.

Outcomes

aOR (95% CI)

p value

C

T

A

47.9%

F ≥ 3

2.01 (1.19;3.40)

0.007

    

APRI ≥1.5

1.98 (1.06;3.71)

0.028

    

FIB4 ≥3.25

2.69 (1.10;6.60)

0.023

    

A3

NA

C

A

G

31.5%

F ≥ 3

0.42 (0.22;0.78)

0.004

    

APRI ≥1.5

0.45 (0.22;0.94)

0.026

    

FIB4 ≥3.25

0.24 (0.07;0.76)

0.007

    

A3

NA

T

A

A

20.1%

F ≥ 3

0.86 (0.44;1.67)

0.647

    

APRI ≥1.5

0.92 (0.42;2.04)

0.838

    

FIB4 ≥3.25

1.07 (0.35;3.26)

0.904

    

A3

NA

  1. P values were calculated by multivariate logistic regression adjusted by the most important clinical and epidemiological characteristics (see “Statistical analysis” section). Statistically significant differences are shown in italics.
  2. 95% CI 95% of confidence interval, aOR adjusted odds ratio, p value level of significance, A3 severe activity grade (Metavir), F  3 advanced liver fibrosis (Metavir), APRI aspartate aminotransferase to platelet ratio index, NA not available due to a low number of patients in one of the groups.