Skip to main content

Table 2 Relationship between IL7RA polymorphisms and severe liver disease in HIV/HCV-coinfected patients

From: Association between IL7R polymorphisms and severe liver disease in HIV/HCV coinfected patients: a cross-sectional study

  Unadjusted Adjusted
CT/TT CC Pa aOR (95% CI) pb
(A) rs6897932
 F ≥ 3 20.5% (17/83) 23.4% (32/137) 0.619 1.14 (0.54;2.32) 0.735
 APRI ≥1.5 15% (12/80) 18.6% (24/129) 0.502 1.14 (0.48;2.68) 0.770
 FIB4 ≥3.25 10% (8/80) 9.3% (12/129) 0.868 0.80 (0.25;2.56) 0.705
 A3 4.9% (4/82) 14.9% (20/134) 0.023 4.16 (1.19;14.59) 0.026
  Unadjusted Adjusted
AA/AT TT Pa aOR (95% CI) pb
(B) rs987106
 F ≥ 3 18.8% (32/170) 34.7% (17/49) 0.019 3.09 (1.32;7.22) 0.009
 APRI ≥1.5 14.3% (23/161) 27.7% (13/47) 0.033 1.84 (0.72;4.70) 0.201
 FIB4 ≥3.25 7.5% (12/161) 17% (8/47) 0.050 2.33 (0.67;8.05) 0.181
 A3 10.1% (17/168) 14.9% (7/47) 0.358 1.82 (0.63;5.23) 0.269
  Unadjusted Adjusted
AG/GG AA Pa aOR (95% CI) pb
(C) rs3194051
 F ≥ 3 16.7% (20/120) 29.3% (29/99) 0.026 2.73 (1.22;5.87) 0.010
 APRI ≥1.5 11.5% (13/113) 24.2% (23/95) 0.016 2.52 (1.10;5.77) 0.029
 FIB4 ≥3.25 5.3% (6/113) 14.7% (14/95) 0.022 4.01 (1.17;13.71) 0.027
 A3 12.6% (15/119) 9.4% (9/96) 0.455 0.79 (0.30;2.10) 0.634
  1. Statistically significant differences are shown in italics.
  2. HCV hepatitis C virus, HIV human immunodeficiency virus, CHC chronic hepatitis C, 95% CI 95% of confidence interval, aOR adjusted odds ratio, p value level of significance, A3 severe activity grade (Metavir), F  3 advanced liver fibrosis (Metavir), APRI aspartate aminotransferase to platelet ratio index.
  3. ap values were calculated by Chi squared test.
  4. bp values were calculated by multivariate logistic regression adjusted by the most important clinical and epidemiological characteristics (see “Statistical analysis” section).