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Table 2 Relationship between IL7RA polymorphisms and severe liver disease in HIV/HCV-coinfected patients

From: Association between IL7R polymorphisms and severe liver disease in HIV/HCV coinfected patients: a cross-sectional study

 

Unadjusted

Adjusted

CT/TT

CC

Pa

aOR (95% CI)

pb

(A) rs6897932

 F ≥ 3

20.5% (17/83)

23.4% (32/137)

0.619

1.14 (0.54;2.32)

0.735

 APRI ≥1.5

15% (12/80)

18.6% (24/129)

0.502

1.14 (0.48;2.68)

0.770

 FIB4 ≥3.25

10% (8/80)

9.3% (12/129)

0.868

0.80 (0.25;2.56)

0.705

 A3

4.9% (4/82)

14.9% (20/134)

0.023

4.16 (1.19;14.59)

0.026

 

Unadjusted

Adjusted

AA/AT

TT

Pa

aOR (95% CI)

pb

(B) rs987106

 F ≥ 3

18.8% (32/170)

34.7% (17/49)

0.019

3.09 (1.32;7.22)

0.009

 APRI ≥1.5

14.3% (23/161)

27.7% (13/47)

0.033

1.84 (0.72;4.70)

0.201

 FIB4 ≥3.25

7.5% (12/161)

17% (8/47)

0.050

2.33 (0.67;8.05)

0.181

 A3

10.1% (17/168)

14.9% (7/47)

0.358

1.82 (0.63;5.23)

0.269

 

Unadjusted

Adjusted

AG/GG

AA

Pa

aOR (95% CI)

pb

(C) rs3194051

 F ≥ 3

16.7% (20/120)

29.3% (29/99)

0.026

2.73 (1.22;5.87)

0.010

 APRI ≥1.5

11.5% (13/113)

24.2% (23/95)

0.016

2.52 (1.10;5.77)

0.029

 FIB4 ≥3.25

5.3% (6/113)

14.7% (14/95)

0.022

4.01 (1.17;13.71)

0.027

 A3

12.6% (15/119)

9.4% (9/96)

0.455

0.79 (0.30;2.10)

0.634

  1. Statistically significant differences are shown in italics.
  2. HCV hepatitis C virus, HIV human immunodeficiency virus, CHC chronic hepatitis C, 95% CI 95% of confidence interval, aOR adjusted odds ratio, p value level of significance, A3 severe activity grade (Metavir), F ≥ 3 advanced liver fibrosis (Metavir), APRI aspartate aminotransferase to platelet ratio index.
  3. ap values were calculated by Chi squared test.
  4. bp values were calculated by multivariate logistic regression adjusted by the most important clinical and epidemiological characteristics (see “Statistical analysis” section).
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Journal of Translational Medicine

ISSN: 1479-5876

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