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Figure 4 | Journal of Translational Medicine

Figure 4

From: Beneficial effects of levobupivacaine regional anaesthesia on postoperative opioid induced hyperalgesia in diabetic mice

Figure 4

Histology of mouse hindpaws. The effect of levobupivacaine and sufentanil were tested on histopathology of diabetic and non-diabetic mouse hind paws at different days postsurgery: a non-diabetic mice 1 day (D1) after skin incision showing acute inflammatory infiltration with polynuclear cells and oedema. b Non-diabetic mice 7 days (D7) after skin incision showing myofibroblastic proliferation with some lymphocyte inflammatory cells. c Non-diabetic mice 14 days (D14) after skin incision showing wound healing of the conjunctive tissue with only few inflammatory cells and still fibroblastic superficial proliferation. d Non-diabetic mice with RA at D14 showing wound healing of the conjunctive tissue with only few inflammatory cells and still fibroblastic superficial proliferation. e Diabetic mice at D1 showing acute inflammatory infiltration with polynuclear cells and oedema. f Diabetic mice at D7 showing persistent acute inflammatory cells and oedema. g Diabetic mice at D14 showing persistent acute inflammatory cells and oedema. h Diabetic mice with regional anaesthesia at D14 showing wound healing of the conjunctive tissue with only few inflammatory cells and still fibroblastic superficial proliferation.

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