Figure 4From: Beneficial effects of levobupivacaine regional anaesthesia on postoperative opioid induced hyperalgesia in diabetic miceHistology of mouse hindpaws. The effect of levobupivacaine and sufentanil were tested on histopathology of diabetic and non-diabetic mouse hind paws at different days postsurgery: a non-diabetic mice 1 day (D1) after skin incision showing acute inflammatory infiltration with polynuclear cells and oedema. b Non-diabetic mice 7 days (D7) after skin incision showing myofibroblastic proliferation with some lymphocyte inflammatory cells. c Non-diabetic mice 14 days (D14) after skin incision showing wound healing of the conjunctive tissue with only few inflammatory cells and still fibroblastic superficial proliferation. d Non-diabetic mice with RA at D14 showing wound healing of the conjunctive tissue with only few inflammatory cells and still fibroblastic superficial proliferation. e Diabetic mice at D1 showing acute inflammatory infiltration with polynuclear cells and oedema. f Diabetic mice at D7 showing persistent acute inflammatory cells and oedema. g Diabetic mice at D14 showing persistent acute inflammatory cells and oedema. h Diabetic mice with regional anaesthesia at D14 showing wound healing of the conjunctive tissue with only few inflammatory cells and still fibroblastic superficial proliferation.Back to article page