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Figure 3 | Journal of Translational Medicine

Figure 3

From: MiR-21: an environmental driver of malignant melanoma?

Figure 3

Working model of exogenous and endogeneous factors that increase exosomal miR-21 signaling in malignant melanoma. The common BRAF(V600E) and NRAS(G12D) mutations in cutaneous melanoma increase miR-21 expression by upregulating AP-1 and STAT3. Keratinocyte-derived exosomal miR-21 induced by UV-irradiation, exosomal miR-21 derived from the systemic circulation induced by dietary and environmental factors as well as obesity- and inflammation-associated exosomal miR-21 may enhance the total burden of miR-21 signaling of melanocytes promoting the transition to the malignant phenotype.

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