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Figure 2 | Journal of Translational Medicine

Figure 2

From: MiR-21: an environmental driver of malignant melanoma?

Figure 2

MiR-21 amplifies NRAS-BRAF-signaling by targeting Sprouty, enhances PI3K-AKT-mTORC1-signaling by targeting PTEN and PDCD4 enhances TGFβ signaling by suppression of SMAD7. Note: c-Jun is an activating transcription factor of MIR21, whereas FOXO3a suppresses MIR21; AKT-mediated phosphorylation of FOXO3a derepresses MIR21; miR-21 target mRNAs are labelled in yellow; asterisk indicates common mutations in malignant cutaneous melanoma.

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