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Fig. 10 | Journal of Translational Medicine

Fig. 10

From: Discordant circulating fetal DNA and subsequent cytogenetics reveal false negative, placental mosaic, and fetal mosaic cfDNA genotypes

Fig. 10

Case 6. Right DAPI stained interphase nuclei with three chromosome 21 centromeres labeled in red and green and two chromosome 21 centromeres labeled with control chromosome 13 centromere probe labeled in green. This confirms that three copies of the Down Syndrome critical region are found in each nucleus and therefore the above karyotype will result in Down Syndrome. Left The normal Y chromosome centromere is labeled in red, the normal X chromosome centromere in green, and to different since normal chromosome 18 centromeres labeled in aqua reflect a normally variable difference in the number of centromeric repeats.

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