Systemic immunity shapes the oral microbiome and susceptibility to bisphosphonate-associated osteonecrosis of the jaw

Table 3 The relationship between quantitative (Bray-Curtis Dissimilarity) and qualitative (Jaccard Dissimilarity) beta diversity measures of the oral microbiome and the expression of genes related to immune system, wound healing and barrier function

	r ² for Bray-Curtis	p value	r ² for Jaccard	p value
Cytokines
RANK	0.0872	0.040	0.0723	0.028
RANKL	0.0611	0.089	0.0395	0.171
TNFA	0.1169	0.010	0.0176	0.542
IL17	0.0073	0.810	0.0138	0.573
IFNG	0.0256	0.419	0.0305	0.366
IL1B	0.0677	0.095	0.0364	0.192
Growth and wound healing factors
FGF9	0.0271	0.281	0.0298	0.247
GMCSF	0.0391	0.168	0.0438	0.140
CTGF	0.0319	0.230	0.0404	0.144
MMP7	0.0235	0.328	0.0267	0.263
MMP9	0.0177	0.462	0.0245	0.298
Response to challenge (endogenous or exogenous)
AHR	0.0721	0.027	0.0768	0.034

ISSN: 1479-5876