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Table 2 Frequencies of the alleles and genotypes of the A20 polymorphisms in RA patients (case) and healthy individuals (control)

From: Characteristics of A20 gene polymorphisms and clinical significance in patients with rheumatoid arthritis

SNPs

Genotype frequency n (%)

Allele frequency n (%)

Major homozygote

Heterozygote

Minor homozygote

 

Major allele

Minor allele

rs5029937

GG

GT

TT

 

G

T

 Case

48 (96.0)

2 (4.0)

0 (0)

 

98 (98.0)

2 (2.0)

 Control

28 (93.3)

2 (6.7)

0 (0)

 

58 (96.7)

2 (3.3)

 p-value

–

1.000

  

–

1.000

rs3799491

GG

GA

AA

GA/AA

G

A

 Case

38 (76.0)

11 (22.0)

1 (2.0)

12 (24)

87 (87.0)

13 (13.0)

 Control

21 (70.0)

9 (30.0)

0 (0)

9

51 (85.0)

9 (15.0)

 p-value

–

0.454

1.000*

0.555

–

0.722

rs598493

CC

TC

TT

 

C

T

 Case

44 (88.0)

6 (12.0)

0 (0)

 

94 (94.0)

6 (6.0)

 Control

26 (86.7)

4 (13.3)

0 (0)

 

56 (93.3)

4 (6.7)

 p-value

–

1.000

  

–

1.000

rs2307859

–/CCT

Wild type

    

 Case

48 (96.0)

2 (4.0)

    

 Control

30 (100)

0 (0)

    

 p-value

–

0.525*

    

rs146534657

AA

AG

GG

 

A

G

 Case

48 (96.0)

2 (4.0)

0 (0)

 

98 (98.0)

2 (2.0)

 Control

30 (100)

0 (0)

0 (0)

 

60 (100)

0 (0)

 p-value

–

0.525*

  

–

0.528*

rs2230926

TT

TG

GG

 

T

G

 Case

47 (94.0)

3 (6.0)

0 (0)

 

97 (97.0)

3 (3.0)

 Control

28 (93.3)

2 (6.7)

0 (0)

 

58 (96.7)

2 (3.3)

 p-value

–

1.000

  

–

1.000

rs661561

CC

AC

AA

AC/AA

C

A

 Case

41 (82.0)

8 (16.0)

1 (2.0)

9 (18)

90 (90.0)

10 (10.0)

 Control

24 (80)

6 (20)

0 (0)

6 (20)

54 (90.0)

6 (10.0)

 p-value

–

0.678

1.000*

0.824

–

1.000

rs582757

TT

CT

CC

 

T

C

 Case

44 (88.0)

6 (12.0)

0 (0)

 

94 (94.0)

6 (6.0)

 Control

26 (86.7)

4 (13.3)

0 (0)

 

56 (93.3)

4 (6.7)

 p-value

–

1.000

  

–

1.000

  1. n number of participants.
  2. * Fisher’s exact p value.