Analysis of multivariate longitudinal kidney function outcomes using generalized linear mixed models

Table 2 Percent reduction in mean difference and mean squared difference that correspond to: SPRI compared to all other multivariate models (a, b, and c)^b; SPRI compared to SHRI (d); SPRIS compared to SHRIS (e); SPRI compared to SPRIS(f)

	Estimate	Outcome	(a) SPRI vs SHRI	(b) SPRI vs SHRIS	(c) SPRI vs SPRIS	(d) SPRI vs SHRl^d	(e) SPRIS vs SHRIS^e	(f) SPRI vs SPRIS^f
Mean difference	Intercept	BUN	4%	15%	33%	4%	(–)^c	33%
		Creatinine	(–)^a	(–)	(–)	14%	89%	(–)^c
		eGFR	(–)	(–)	(–)	12%	63%	(–)
	Time	BUN	(–)	(–)	(–)	(–)^c	(–)	96%
		Creatinine	84%	82%	86%	84%	(–)	86%
		eGFR	85%	85%	54%	85%	67%	74%
Mean squared difference	Intercept	BUN	(–)	(–)	(–)	(–)	(–)	5%
		Creatinine	(–)	(–)	(–)	(–)	(–)	1%
		eGFR	(–)	(–)	(–)	(–)	(–)	28%
	Time	BUN	2%	2%	11%	2%	(–)	11%
		Creatinine	10%	9%	2%	10%	7%	2%
		eGFR	32%	35%	6%	32%	31%	6%

^aSPRI did not generate the smallest mean difference and/or mean squared difference compared to all multivariate models.
^b50% of the estimates under SPRI had the smallest mean difference and mean squared difference compared to all other models with 58.7% and 12% average overall reduction respectively.
^cNo reduction was observed under SPRI or SPRIS.
^d83% of the estimates under SPRI had smaller mean difference compared to SHRI with average overall reduction of 40%, and 50% had smaller mean squared difference with average reduction of 15%.
^e50% of the estimates under SPRIS had smaller mean difference compared to SHRIS with average overall reduction of 73%, and 33% had smaller mean squared difference with average reduction of 19%.
^f66% of the estimates under SPRI had smaller mean difference compared to SPRIS with average overall reduction of 72%, and 100% had smaller mean squared difference with average reduction of 9%.

ISSN: 1479-5876