Figure 4

Vemurafenib and sunitinib treatment inhibits tumor growth in mice inoculated with human melanoma xenografts. Male NOD SCID mice bearing tumors derived from human A375 melanoma cells were fed daily with 75 mg/kg of vemurafenib and 20 mg/kg of sunitinib (a, c) or 1 mg/kg of lapatinib, which was used as the control (b, d), for 10 days. The tumor size (a, b) and body weights (c, d) of each mouse were measured every 2 days as indicated.