The effects of phosphodiesterase-5 inhibitor sildenafil against post-resuscitation myocardial and intestinal microcirculatory dysfunction by attenuating apoptosis and regulating microRNAs expression: essential role of nitric oxide syntheses signaling

Table 2 Arterial blood gasses during cardiopulmonary resuscitation and after return of spontaneous circulation

Group	Parameter	Baseline	ROSC 0 min	ROSC 30 min	ROSC 1 h	ROSC 2 h	ROSC 4 h	ROSC 6 h
Saline group	PH	7.41 ± 0.11	7.21 ± 0.05**	7.23 ± 0.07**	7.24 ± 0.06**	7.27 ± 0.09**	7.30 ± 0.08**	7.32 ± 0.09*
	PaO₂ (mmHg)	89.1 ± 9.3	44.5 ± 4.7**	55.4 ± 5.1**	60.1 ± 6.2**	70.2 ± 7.1**	79.5 ± 7.7*	80.7 ± 7.5*
	PaCO₂ ⁻ (mmHg)	39.3 ± 3.2	48.3 ± 5.1**	46.7 ± 5.4**	45.4 ± 4.1**	43.8 ± 4.7*	41.6 ± 4.2	41.5 ± 4.8
	HCO₃ ⁻ (mmol/L)	27.2 ± 4.7	19.3 ± 1.2**	20.4 ± 1.6**	21.6 ± 2.7**	22.7 ± 2.6**	24.5 ± 3.1*	25.2 ± 3.7
	Lactate (mmol/L)	2.6 ± 0.5	11.2 ± 3.3**	9.3 ± 2.7**	8.8 ± 1.9**	6.9 ± 2.2**	5.8 ± 1.3*	4.1 ± 1.1
Sildenafil group	PH	7.42 ± 0.13	7.27 ± 0.07**^Δ	7.29 ± 0.04*^Δ	7.30 ± 0.07*^Δ	7.32 ± 0.05*	7.35 ± 0.04*	7.38 ± 0.11
	PaO₂ (mmHg)	90.2 ± 8.6	52.7 ± 5.3**^Δ	63.5 ± 6.2**^Δ	70.3 ± 7.1**^Δ	79.3 ± 7.7*^Δ	83.5 ± 8.1*	84.9 ± 8.2
	PaCO₂ ⁻ (mmHg)	39.5 ± 3.4	44.7 ± 4.3*^Δ	43.2 ± 4.4*^Δ	42.4 ± 4.1*	41.3 ± 4.2	40.5 ± 4.2	41.1 ± 3.8
	HCO₃ ⁻ (mmol/L)	27.6 ± 4.1	22.6 ± 2.7**^Δ	23.7 ± 2.6**^Δ	24.6 ± 2.7*^Δ	25.3 ± 2.6	25.7 ± 3.1	26.3 ± 3.8
	Lactate (mmol/L)	2. 7 ± 0.4	9.5 ± 2.4**^Δ	8.1 ± 2.1**^Δ	7.4 ± 1.6**^Δ	5.3 ± 1.3**^Δ	4.2 ± 1.2*^Δ	3.6 ± 0.7

Values are mean ± SD.
* p < 0.05 vs. baseline, ** p < 0.01 vs. baseline, ^Δp < 0.05 vs. saline. (Student t test was used for comparisons between every two groups. Partial pressures are given in mmHg. HCO₃ ⁻: bicarbonate in mM; Differences at different time points were compared with repeated-measures analysis of variance (ANOVA) with Bon-ferroni correction for post hoc comparison between multiple experimental groups).

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