Histological and laboratory evaluations of renal function in the early stage of post burn. Representative HE-staining images of different paired groups (saline or HS treatment) manifested histological evidence of renal tubular damage at different time points post burn at a magnification of ×400. Several injurious changes appeared on the renal tubules after burn insult (a
upper row); HS treatment resulted in an attenuation of these effects (a
lower row). Furthermore, the tubular damage scores provided quantitative verification (b). With respect to the blood examination, serum creatinine (c) and NGAL (d) levels showed similar remarkable elevations after burn, which indicated the development of burn-induced early renal dysfunction. The sample size was n = 8 for each group. The results were expressed as the means ± SEMs. **p < 0.01, vs Burn + saline; #p < 0.05, ##p < 0.01, vs Sham.