Figure 4

A module with a significantly discriminative score as mDEG + mDEVG + mDECG but not as mDEG. This module has significant discriminative scores of samples from control and case groups, whose DEGs are in red, DEVGs are in blue and DECGs are in pink. Particularly, in this module, SRPK1 and SFRS4 are DEGs; SFRS3 and SFRS21P are DEVGs; meanwhile, and SFRS5 is DECG because it has significantly differential correlation with SRPK1. Obviously, in the conventional differential expression analysis, only SRPK1 and SFRS4 are selected and measured in the downstream analysis, meanwhile other feature genes would be under-estimated.