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Figure 2 | Journal of Translational Medicine

Figure 2

From: Excessive proliferation and impaired function of primitive hematopoietic cells in bone marrow due to senescence post chemotherapy in a T cell acute lymphoblastic leukemia model

Figure 2

Primitive hematopoietic cells showed an earlier regeneration than leukemic cells post therapy. a Representative flow cytometry plots of leukemic cells in the BM of the 1-day treated leukemic mice on the therapeutic day (d0), and on the 1st, 2nd, 5th, and 12th day post therapy. b Representative flow cytometry plots of CD45.2+LK+S+ and CD45.2+LK+S cells in the BM of normal control (shown as N) and the 1-day treated leukemic mice post therapy. Cells were gated in CD45.2+Lin populations. c Frequencies of leukemic cells in whole MNCs and CD45.2+LK+S and CD45.2+LK+S+ cells in CD45.2+ hematopoietic cell fractions in the BM of the 1-day treated leukemic mice on the therapeutic day (d0) and following days (n = 3–4). d Total numbers of leukemic cells, CD45.2+LK+S and CD45.2+LK+S+ cells in the BM (double hindlimbs) of the 1-day treated leukemic mice on different time (n = 3–4). e Frequencies of CMP, GMP, and MEP in CD45.2+LK+S cells in the BM of normal control and the 1-day treated leukemic mice on different time (n = 3–8). f Frequencies of LT-HSC, ST-HSC, and MPP in CD45.2+LK+S+ cells in the BM of normal control and the 1-day treated leukemic mice on different time (n = 3–9). gj Total numbers of LT-HSC, ST-HSC, MPP, and CD45.2+LK+S+ cells of the leukemia-only control and the 1-day treated leukemic mice in BM (double hindlimbs) on different days (n = 3–6). kn Frequencies of LT-HSC, ST-HSC, MPP and CD45.2+LK+S+ cells in CD45.2+ hematopoietic cell fractions in the BM of the leukemia-only control and the 1-day treated leukemic mice on different days (n = 3–6). All data were presented as mean ± SEM. Statistical significance determined as: *p < 0.05; **p < 0.01; ***p < 0.001.

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