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Table 4 The differentially expressed metabolites between SZ and MD group

From: Severe disturbance of glucose metabolism in peripheral blood mononuclear cells of schizophrenia patients: a targeted metabolomic study

Metabolites

Metabolic pathway

Training set

Test set

Log2(FC)a

P valueb

Log2(FC)a

P valueb

Glucose

Glycosis

3.73

0.000

0.32

0.071

Glucose 6-phosphate

Glycosis

1.09

0.000

1.10

0.000

Fructose 6-phosphate

Glycosis

0.85

0.000

0.88

0.001

Fructose

Glycosis

6.04

0.000

0.19

0.342

Glyceraldehyde-3-phosphate

Glycosis

−1.83

0.000

−0.80

0.114

Dihydroxyacetone phosphate

Glycosis

−2.99

0.000

−0.49

0.849

Glycerol 3-phosphate

Glycosis

−0.52

0.000

−0.39

0.020

Glycerate 3-phosphate

Glycosis

1.59

0.000

0.56

0.022

Pyruvate

Glycosis

0.2

1.000

0.60

0.057

Lactic acid

Glycosis

0.04

1.000

−0.48

0.198

Citric acid

TCA

−0.98

0.000

−0.60

0.008

Succinic acid

TCA

3.01

0.000

0.06

1.000

Ribose 5-phosphate

Pentose phosphate pathway

4.56

0.000

−0.23

0.820

  1. Values given in bold denote statistically significant results (P < 0.05).
  2. SZ schizophrenia, MD major depression, FC fold change, TCA tricarboxylic acid cycle.
  3. aA negative log2(FC) indicated significantly lower expression in schizophrenia subjects compared to major depressive subjects; a positive log2(FC) indicated significantly higher expression in schizophrenia subjects compared to major depressive subjects.
  4. bThese data were analyzed using one-way ANOVA followed by Bonferroni post hoc test between two groups of each cohort.