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Figure 4 | Journal of Translational Medicine

Figure 4

From: Recovery of a human natural antibody against the noncollagenous-1 domain of type IV collagen using humanized models

Figure 4

Humanized mouse and healthy human donor B cell subset analysis. ac Representative flow cytometric analysis after gating on human CD45+ CD19+ live cells. The Hu-PBL (a) and alpha3(IV)NC1 collagen-immunized Hu-HSC (c) mice are 14 and 162 days post engraftment, respectively. Percentage of gated cells are indicated. d %CD27+ CD38+ expression on intermediate-to-high CD19+ B cells from splenocytes of Hu-PBL mice engrafted with healthy donor PBL, gated as shown in (a).

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