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Figure 2 | Journal of Translational Medicine

Figure 2

From: Recovery of a human natural antibody against the noncollagenous-1 domain of type IV collagen using humanized models

Figure 2

Engraftment of NSG mice with PBL from two patients with anti-GBM glomerulonephritis. NSG mice were injected with PBL from glomerulonephritis patients (GP) (circles) or from a healthy control subject (HC) (triangles), or were unengrafted (squares). Shown are spleen weight and cell count (a, b), % chimerism (c), serum immunoglobulin levels (d), and % human B cells (e) and T cells (f) in tissue compartments. Each symbol represents an individual Hu-PBL mouse. Chimerism was calculated as described in “Methods”. PBL peripheral blood leukocytes, BM bone marrow; *p < 0.05.

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