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Table 3 NK (CD3−CD16+CD56dim) cells expressing granzyme B/perforin (cytotoxic activity) and NKG2D (activation) in the circulation of women with LLABCs and HFDS

From: Natural killer (NK) cell profiles in blood and tumour in women with large and locally advanced breast cancer (LLABC) and their contribution to a pathological complete response (PCR) in the tumour following neoadjuvant chemotherapy (NAC): differential restoration of blood profiles by NAC and surgery

Cell phenotypes and functional status

% in the circulation of women with LLABCs (n = 25)

% In the circulation of HFDs (n = 10)

P value

NK granzyme B+/perforin+

43.41 ± 4.00

60.26 ± 7.00

0.003*

NK-NKG2D+

8.32 ± 3.50

4.00 ± 1.50

0.078

  1. LLABCs large (≥3 cm) and locally advanced breast cancers (T3–4 N1–2 M0), HFDs healthy female donors.
  2. * Values significantly reduced.