Table 4 Comparison of EGFR and HER2 mRNA expression with EGFR protein expression and HER2 status, respectively
EGFR mRNA (cut-off at 75%) | EGFR protein expression (N = 625) | NPV/PPV (%) | Sensitivity (%) | Specificity (%) | |
|---|---|---|---|---|---|
Negative | Positive | ||||
Low | 442 (83.1%) | 30 (32.3%) | 93.6/41.2 | 67.7 | 83.1 |
High | 90 (16.9%) | 63 (67.7%) | |||
HER2 mRNA (cut-off at 50%) | HER2 (IHC/FISH) (N = 632) | NPV/PPV (%) | Sensitivity (%) | Specificity (%) | |
|---|---|---|---|---|---|
Negative | Positive | ||||
Low | 305 (62.4%) | 11 (7.7%) | 96.5/41.8 | 92.3 | 62.4 |
High | 184 (37.6%) | 132 (92.3%) | |||