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Table 1 Mean (±SD) pharmacokinetic parameters of fospropofol following fospropofol administration in rats

From: Gastrointestinal delivery of propofol from fospropofol: its bioavailability and activity in rodents and human volunteers

Route Dose (mg/kg) Cmax (µg/mL) AUC(0−t) (µg h/mL) AUC0−∞ (µg h/mL) T1/2 (h) Vd (L/kg) CLp (L/h/kg) Fa (%)
IV 5 16.3 (±1.80) 3.15 (±0.29) 3.15 (±0.28) 0.49 (±0.28) 1.02 (±0.66) 1.38 (±0.125)
PO 20 0.23 (±0.07) 0.05 (±0.008) 0.06 (±0.007) 0.19 (±0.27) 0.448
PO 100 9.23 (±4.09) 2.16 (±0.99) 2.18 (±0.99) 0.49 (±0.24) 3.46
ID 30 0.17b 0.044 0.05 0.21nd 0.264
ID 100 3.74 (±2.12) 0.644 (±0.38) 0.65 (±0.39) 0.23 (±0.1) 1.03
  1. nd not determined as only one rat showed terminal elimination.
  2. aRatio of mean of AUC(0−∞) to reference treatment of 5 mg/kg IV fospropofol.
  3. bN = 1.