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Table 1 Mean (±SD) pharmacokinetic parameters of fospropofol following fospropofol administration in rats

From: Gastrointestinal delivery of propofol from fospropofol: its bioavailability and activity in rodents and human volunteers

Route

Dose (mg/kg)

Cmax (µg/mL)

AUC(0−t) (µg h/mL)

AUC0−∞ (µg h/mL)

T1/2 (h)

Vd (L/kg)

CLp (L/h/kg)

Fa (%)

IV

5

16.3 (±1.80)

3.15 (±0.29)

3.15 (±0.28)

0.49 (±0.28)

1.02 (±0.66)

1.38 (±0.125)

PO

20

0.23 (±0.07)

0.05 (±0.008)

0.06 (±0.007)

0.19 (±0.27)

0.448

PO

100

9.23 (±4.09)

2.16 (±0.99)

2.18 (±0.99)

0.49 (±0.24)

3.46

ID

30

0.17b

0.044

0.05

0.21nd

0.264

ID

100

3.74 (±2.12)

0.644 (±0.38)

0.65 (±0.39)

0.23 (±0.1)

1.03

  1. nd not determined as only one rat showed terminal elimination.
  2. aRatio of mean of AUC(0−∞) to reference treatment of 5 mg/kg IV fospropofol.
  3. bN = 1.