Figure 3

Analgesic effect of orally administered fospropool in rat chronic constrictive injury model of neuropathic pain. Withdrawal latency measurements were taken starting 45–60 min post-dose. Fospropofol was effective in reducing hyperalgesia at doses of 75 and 100 mg/kg (a). This effect was not due to a non-selective sedative effect as latency on the non-ligated side did not change with fospropofol treatment (b). n = 10 rats per group. p < 0.05 vs vehicle noted as “*”. Data shown as mean ± SEM.