Figure 3
From: Novel and rare functional genomic variants in multiple autoimmune syndrome and Sjögren’s syndrome
Network analysis illustrating the function of MICAL1 in autoimmune related processes. Of particular importance in the network is the interaction between protein kinase C mu and MICAL. The MICAL protein is highlighted with a circular yellow dot (as was the case for the A2M receptor in Figures 1 and 2) because it is encoded by the MICAL1 that was part of the user generated input list for the MetaCore network-building algorithm. The mechanistic nature of the protein interactions in the network are as follows: P phosphorylation. The downstream effects exhibited by protein–protein interactions between a given set of nodes are represented by the following: pink activation by phosphorylation, grey phosphorylation with unspecified effect.