Network analysis illustrating the function of MICAL1 in autoimmune related processes. Of particular importance in the network is the interaction between protein kinase C mu and MICAL. The MICAL protein is highlighted with a circular yellow dot (as was the case for the A2M receptor in Figures 1 and 2) because it is encoded by the MICAL1 that was part of the user generated input list for the MetaCore network-building algorithm. The mechanistic nature of the protein interactions in the network are as follows: P phosphorylation. The downstream effects exhibited by protein–protein interactions between a given set of nodes are represented by the following: pink activation by phosphorylation, grey phosphorylation with unspecified effect.