Diverse functions of miR-373 in cancer

Table 2 Summaries of representative studies investigating the role of miR-373 in clinical samples

Tumor type	Sample type	miR-373 expression levels^a	miR-373 function	References
TGCT	Primary tumor tissue	↑	oncogene	[7, 51]
TGCT	serum	↑	oncogene	[53, 54]
Breast cancer	Primary tumor tissue and metastatic lymph nodes	↑	oncogene	[8]
Breast cancer (ER⁻)	Primary tumor tissue	↓	TSG	[22]
Breast cancer	serum	↑	oncogene	[26, 59–61]
HB	Primary tumor tissue		oncogene	[33]
HCC	Primary tumor tissue	↑	oncogene	[14, 29, 33]
Hilar cholangiocarcinoma	Primary tumor tissue	↓	TSG	[13, 34, 35]
Gastric cancer	Primary tumor tissue	↑	oncogene	[20]
Esophageal cancer	Primary tumor tissue	↑	oncogene	[10]
Colon cancer	Primary tumor tissue	↓	TSG	[16]
Prostate cancer	Primary tumor tissue	↓	Oncogene	[11]
Thyroid adenoma	Primary tumor tissue	↑	Oncogene	[32]
Pancreatic cancer	Primary tumor tissue	↓	TSG	[31]
Lung cacner	Primary tumor tissue	↓	TSG	[23]

TGCT testicular germ cell tumor, ER ⁻ estrogen receptor negative, TSG tumor suppressor gene, HB hepatoblastoma, HCC hepatocellular carcinoma
^a↑represents up-regulation, ↓represents down-regulation

ISSN: 1479-5876