Fig. 1

Regulation network of miR-373. Green boxes display upstream regulators of miR-373, black boxes contain representive functional targets of miR-373, and blue boxes imply the correspondingly involved cellular processes. Upstream factors lead to altered expression of miR-373. miR-373 exerts its functions by suppressing or promoting multiple target genes expression, and is involved in regulation of cell proliferation and growth, cell migration, invasion and metastasis, and DNA damage repair