Fig. 6

Tumorigenicity study: HE and HLA-ABC staining of serial sections of abnormal organs or tissues from five mice of the huChon group. MT1: liver, hepatoma (benign); MT2: colon, small neurinoma (benign); MT3 and MT4: abdominal skin, hair retention cysts (no tumors); MT5: pulmonary lobe, microfocal, benign malformation (no tumor). Thus, only the suspicious areas of mice MT1 and MT2 were classified histopathologically as tumors. However, these tissues were HLA-ABC negative suggesting that they are spontaneous murine rather than human tumors. IHC controls: Sections of human skin stained with the IgG2a isotype control (left) and with the anti-HLA-ABC (right) antibodies served as staining controls. Bars indicate 200 μm