Fig. 4

EnSCs transplantation restores fertility in mice treated with chemotherapy. Reproductive outcomes were assessed over three successive mating rounds in different mouse groups. a Offspring obtained by mating after EnSCs transplantation into mice sterilized by chemotherapy compared with chemoablated group and untreated control. Note the stillbirth in a chemoablated mouse (Arrow). b Mean litter size per pregnant mouse for three litters in each group. Data represent means ± standard error. n = 10 per group. **P < 0.001. c Midline histological sections of ovaries removed after the mating rounds and stained with H&E. Scale bars = 100 μm