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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Development of a novel IGRA assay to test T cell responsiveness to HBV antigens in whole blood of chronic Hepatitis B patients

Fig. 2

Synthetic HBcAg peptides elicit weak IFNγ and IL2 responses during HBV-specific T cell stimulation in whole blood of CHB patients. n = 80 HC, n = 8 AHB patients, n = 40 NUC treatment naive CHB patients and n = 32 NUC treated patients, for each tested HBV antigen. Every HC or patient was tested against HBV peptide pools specific for HBcAg and HBsAg. (a) IFNγ, (b) IL2. Negative control values were deducted from the peptide induced responses. Lower limit of detection (Background + 3x S.D.) was at 2 – 5 pg/ml for IFNγ and IL2. All values are given as mean concentration pg/ml ± S.E.M. ANOVA and Tamhane T2 post hoc tests, following symbol pinpoints significant differences: *. One symbol equals 0.05, two symbols 0.01, three symbols 0.001

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