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Figure 4 | Journal of Translational Medicine

Figure 4

From: Fatty acid synthase overexpression: target for therapy and reversal of chemoresistance in ovarian cancer

Figure 4

Effect of the FASN inhibitors cerulenin and C75 on cell viability. Effect of the FASN inhibitors cerulenin and C75 on cell viability of ovarian cancer cell lines and ex vivo tumor material. The four selected ovarian cancer cell lines, Hey, Heycis, Igrov-1, and Skov-3, and primary ovarian cancer cell cultures G2, G3 #1, and G3 #2 were treated with either 35 μmol/L cerulenin or 35 μmol/L C75. Cell viability was investigated by the MTT assay. Except in the multidrug-resistant cell line Skov-3, the growth of which was hardly affected by either FASN inhibitor, cerulenin (cer) achieved a stronger reduction of cell viability, ≥90% in the other illustrated ovarian cancer cell lines and in two of three primary cancer cell cultures. By contrast, C75 caused <50% inhibition in the Hey and Igrov-1 cell lines and the G2 cell culture and no inhibition in the G3 cell cultures, relative to untreated cells/controls (Ø) (***P < 0.001; **P < 0.01; *P < 0.05).

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