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Table 2 Univariate and multivariable Cox regression analyses for overall and disease-free survival

From: Glutamate dehydrogenase is a novel prognostic marker and predicts metastases in colorectal cancer patients

Factor Univariate analysis Multivariate analysis
HR 95% CI P -value HR 95% CI P -value
Overall survival         
Depth of invasion (T1-2/T3-4) 2.07 1.16 3.69 0.014* 1.82 0.98 3.38 0.060
Tumor stage (I-II/III-IV) 2.01 1.11 3.63 0.021* 1.37 0.72 2.6 0.333
Grade of differentiation (well, moderate/poor) 2.13 1.01 4.45 0.046* 1.28 0.53 3.05 0.581
Lymph node metastasis (negative/positive) 4.68 2.45 8.94 <0.001* 3.47 1.66 7.27 0.001*
Liver metastasis (negative/positive) 3.53 1.88 6.63 <0.001* 2.62 1.29 5.32 0.008*
Venous invasion (negative/positive) 2.45 1.04 5.8 0.042* 1.66 0.64 4.32 0.294
Nervous invasion (negative/positive) 2.25 1.25 4.05 0.007* 1.14 0.59 2.19 0.703
GDH (low/high) 2.32 1.26 4.26 0.007* 2.42 1.23 4.78 0.011*
Disease-free survival        
Lymph node metastasis (negative/positive) 5.73 2.68 12.28 <0.001* 4.70 2.08 10.59 <0.001*
Liver metastasis (negative/positive) 3.81 1.95 7.46 <0.001* 2.38 1.16 4.87 0.018*
GDH (low/high) 2.48 1.25 4.92 0.009* 2.17 1.05 4.47 0.037*
  1. HR relative risk, 95% CI 95% confidence interval.
  2. *Statistically significant P<0.05, Cox proportional hazard regression model.