Table 2 Univariate and multivariable Cox regression analyses for overall and disease-free survival

Overall survival

Depth of invasion (T1-2/T3-4)

2.07

1.16

3.69

0.014*

1.82

0.98

3.38

0.060

Tumor stage (I-II/III-IV)

2.01

1.11

3.63

0.021*

1.37

0.72

2.6

0.333

Grade of differentiation (well, moderate/poor)

2.13

1.01

4.45

0.046*

1.28

0.53

3.05

0.581

Lymph node metastasis (negative/positive)

4.68

2.45

8.94

<0.001*

3.47

1.66

7.27

0.001*

Liver metastasis (negative/positive)

3.53

1.88

6.63

<0.001*

2.62

1.29

5.32

0.008*

Venous invasion (negative/positive)

2.45

1.04

5.8

0.042*

1.66

0.64

4.32

0.294

Nervous invasion (negative/positive)

2.25

1.25

4.05

0.007*

1.14

0.59

2.19

0.703

GDH (low/high)

2.32

1.26

4.26

0.007*

2.42

1.23

4.78

0.011*

Lymph node metastasis (negative/positive)

5.73

2.68

12.28

<0.001*

4.70

2.08

10.59

<0.001*

Liver metastasis (negative/positive)

3.81

1.95

7.46

<0.001*

2.38

1.16

4.87

0.018*

GDH (low/high)

2.48

1.25

4.92

0.009*

2.17

1.05

4.47

0.037*