Figure 5

GDH promotes CRC cell motility via STAT3 mediated EMT Induction. (A) Effects of GDH knockdown and AG490 on STAT3 Tyr705 phosphorylation, ZEB1 Vimentin and E-cadherin protein expression in CRC cells detected by western blot analysis. (B-D) Effects of GDH knockdown on cell proliferation, migration and invasion of CRC cells. Data are presented as the mean ± SD based on three independent experiments. *P < 0.05, **P < 0.01 compared to the control using Student’s t-test.