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Table 1 Patient characteristics of tissue used for generation of patient-derived orthotopic mouse model

From: Establishment of a patient-derived orthotopic osteosarcoma mouse model

Age & Gender

17 years, female

Primary disease

diagnosed April 2008

  - histopathology

osteoblastic osteosarcoma

  - Tumor location

right femur epiphysis, no metastases

  - Treatment

according to EURAMOS 1 06/2008 – 11/2009, abortion of chemotherapy after the third postoperative cycle by request of the patient and her parents

Extraarticular tumor resection of the right femur (09.09.2008) and implantation of a Mutars-Endoprothesis (regression grade II according to Salzer-Kuntschik)

1. Relapse

diagnosed 24 months after diagnose of primary disease

  - histopathology

 - osteoblastic osteosarcoma

  - Location

 - multifocal lesions in the right tibia, both lungs bilateral and the mediastinum

  - treatment

 - no further treatment because of the significant reduced general conditions and by request of the patient and her parents

Death of disease

8 weeks after diagnose of relapse

Family history

- Oldest child of four children

 - Youngest brother died because of an embryonal rhabdomyosarcoma in 2000

 - Mother died because of a Mamma-Ca in 2006

 - Father, one younger sister and one younger brother are healthy

 - Diagnostic concerning familiar tumor predisposition syndrome was declined