Figure 5

Effect of downregulated DNMT1 on cisplatin sensitivity of A549/DDP and SPC-A1/DDP cells. (A) A549/DDP cells were transfected with si-DNMT1. (B) 24 hours after incubation, the cell viability was assessed by MTT assay. (C) SPC-A1/DDP cells were also transfected with si-DNMT1 and (D) its cell viability was evaluated. Data were represented as mean ± SD. *P <0.05 compared with cells treated with the same concentration of ciaplatin accordingly.