Figure 3

Change in tumor expression of p27 from baseline (i.e., before atorvastatin treatment) to time of surgery (i.e., after atorvastatin treatment). A) Fraction of stained nuclei; B) Nuclear intensity; C) Cytoplasmic intensity. To reduce the problem of completely overlapping lines in the spaghetti plot, for each pair of pre/post-treatment samples, a random number from a uniform distribution over the interval [−0.15, 0.15] was added, shifting the corresponding line at most 15%, upwards or downwards, of a step on the integer-valued score scale.