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Figure 2 | Journal of Translational Medicine

Figure 2

From: Statin-induced anti-proliferative effects via cyclin D1 and p27 in a window-of-opportunity breast cancer trial

Figure 2

Change in tumor expression of cyclin D1 from baseline (i.e., before atorvastatin treatment) to time of surgery (i.e., after atorvastatin treatment). A) Fraction of stained nuclei; B) Nuclear intensity; C) Cytoplasmic intensity. To reduce the problem of completely overlapping lines in the spaghetti plot, for each pair of pre/post-treatment samples, a random number from a uniform distribution over the interval [−0.15, 0.15] was added, shifting the corresponding line at most 15%, upwards or downwards, of a step on the integer-valued score scale.

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